Contact Us：
Tel:+86-10-62798332
E-mail: MJZHANG at tsinghua.edu.cn
张明君教授于1996年底获得浙江大学工业自动化工学博士学位，2000年获得美国华盛顿大学(圣路易斯)系统科学和数学/机器人理学博士学位，是美国斯坦福大学生物医学硕士、电子工程硕士，美国密苏里大学计算机科学硕士，浙江大学机械学硕士、机械工程学士。先后任美国硅谷安捷伦科技公司精密仪器及生物芯片研发工程师、田纳西大学生物医学工程系副教授(终身)、俄亥俄州立大学生物医学工程系正教授(终身)。2020年起全职回国分別任教于清华大学医学院和生物医学工程学院，现为清华大学长聘教授、博士生导师。主要从事具身智能脑机接口与脑机智能融合、微纳米机器人和仿生纳米材料交叉学科研究。作为PI主持科技部国家重点研发计划、颠覆性技术创新专项，国自然面上项目、重点项目、重大项目，美国NIH(R01)，NSF，ONR，ARO等逾30项主旨科研项目。作为第一或通讯作者，研究成果发表于 Cell、Cell Device、Nature Nanotechnology 、 Nature Communications 、 Science Advances 、Advanced Science、PNAS、IEEE Transactions 等期刊，并被 Science、Nature、美国国家自然科学基金、美国科学促进会、中国中央电视台和英国广播公司等媒体报道。曾获浙江大学竺可桢奖学金，美国海军研究署年轻科学家奖，IEEE 机器人与自动化学会青年科学家奖。
在具身智能脑机接口领域，团队自主研发了9个系列生物相容柔性微创神经电极，具有高分辨率单神经元记录、微创可展开、传感和刺激双向、光电化学多模态等特性。并开发了3代无线高通量柔性脑机接口微电路芯片系统，采用模块化设计，集成片上高效神经信号压缩、预处理算法，具备低功耗信号采集及多模态闭环调控功能，适配皮层、深部神经元及非侵入式脑电记录等多种应用场景，构建了具有独立知识产权的多场景脑机交互及多模态闭环调控体系。目前已在大小鼠（超1年）、比格犬（超1年4个月）、狨猴（超2年）、猕猴、巴马猪、蝙蝠等模式动物及脑类器官上完成全链条原型系统验证，已完成 37例（至2026年3月）由研究者发起的人上无线脑机接口信号采集及处理系统的临床实验验证，并已与合作者开展面瘫、梅杰综合症、癫痫等典型神经系统疾病的脑机交互及闭环调控研究。
在微纳机器人领域，团队专注于生物自驱动微纳机器人功能模式研究，突破传统生物体外部控制微纳机器人面临的能量供给与操控限制。首次提出肠驱动被动式微针机器人药物递送模式，利用胃肠道蠕动和微环境响应，实现药物的口服递送。首次提出颅骨骨髓免疫细胞药物递送微纳机器人，借助经“颅-脑免疫微通道”天然入脑捷径和骨髓免疫细胞对脑实质病灶的靶向性，实现中枢神经系统药物递送与疾病治疗，为构建新一代“物料流”脑机接口技术开拓了思路，该研究成果已发表于Cell正刊。
基于上述研究基础，团队已开展了融合颅脑微纳机器人给药的具身智能脑机接口交叉学科学术研究。面向现有脑机接口在感知大脑与外部环境状态，及脑疾病自适应多模态精准闭环调控等方面面临的挑战，团队提出“脑-机-环境”深度融合的具身交互与协同调控系统框架，探索数据驱动的非线性神经动力学系统辨识与超前预测算法，针对癫痫等神经系统疾病，构建基于模型的优化控制方法，结合患者实时场景信息，实现长期稳定的自适应最优闭环调控。并集成细胞微纳机器人经颅给药功能，融合急性（电刺激）与长期（药物调节）干预手段，实现异常神经活动的急性干预与病理状态的长期重塑。旨在构建“超常感知、超前决策、超快执行”具身智能神经调控新范式，为中枢神经系统疾病的预估、治疗提供新的思路。
1. Xize Gao, Xiangrong Liu, Chengqian Cui, Nanxing Wang, Weiming Liu, Mo Yang, Qin Li, Yunwei Ou, Aiyi Ning, Meiyang Zhang, Xinyue Wei, Shuowen Qiu, Yang Lei, Dongjie Fu, Huimin Li, Leming Sun, Meng Lu, Mingjun Zhang*, Yilong Wang*. Nanoparticles hijack brain-servo calvarial immune cells to bypass BBB for CNS drug delivery. Cell, 189(5), 1341-1355 (2026).
2. Zhen Fan, Leming Sun, Yujian Huang, Yongzhong Wang and Mingjun Zhang*. Bioinspired Fluorescent Dipeptide Nanoparticles for Targeted Tumor Imaging and Realtime Monitoring of Drug Release, Nature Nanotechnology, 11, 388-394 (2016).
3. Tiancheng Sheng, Lingyi Zheng, Jingwei Li, Nianzhen Du, Xiaolong Wang, Mingxiao Xie, Hongru Liu, Cheng’ ao Xu, Huimin Li, Yong Guo, Jing Xu, Lianqing Liu, Mingjun Zhang*. Modular brain-machine interface for neurorecording, neurostimulation, and drug delivery. Cell Device 3, 100687 (2025).
4. Zhen Fan, Chaochu Cui, Yan Chang, Leming Sun, Fan Yuan, Zui Pan*, Mingjun Zhang*. Near-infrared Fluorescent Peptide Nanoparticles for Enhancing Esophageal Cancer Therapeutic Efficacy. Nature Communications, 9, 2605 (2018).
5. Kai Tao, Zhen Fan, Leming Sun, Pandeeswar Makam, Zhen Tian, Mark Ruegsegger, Shira Shaham-Niv, Derek Hansford, Ruth Aizen, Zui Pan, Scott Galster, Jianjie Ma, Fan Yuan, Mingsu Si, Songnan Qu, Mingjun Zhang*, Ehud Gazit*, Junbai Li*. Quantum Confined Peptide Assemblies with Tunable Visible to Near-Infrared Spectral Range. Nature Communications, 9, 3217 (2018).
6. Xize Gao, Jiacong Li, Jing Li, Mingjun Zhang*, Jing Xu*. Pain-free Oral Delivery of Biologic Drugs using Intestinal Peristalsis Actuated Microneedle Robots. Science Advances, 10(1): eadj7067 (2024).
7. Tao Yue, Xinghua Jia, Jennifer Petrosino, Dong Wang, Jesse Fine, Scott Galster, Rebecca Davis, Doug Scharre, Mingjun Zhang*. Computational integration of nano-scale physical biomarkers and cognitive assessments to diagnose and predict the progression of Alzheimer’s disease. Science Advances, 3, e1700669 (2017).
8. Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao*, Xinjian Li* and Mingjun Zhang*. Deciphering neural mechanisms underlying marmoset dynamic natural behaviors using a miniaturized wireless large-scale coverage neural recorder. Advanced Science, 13(2), e07110 (2025).
9. Zhiheng Tang, Chengqian Cui, Xiaoli Jing, Rui You* and Mingjun Zhang*, Jing Xu*. Wafer-scale bandgap-tunable MoS2/PbS phototransistors enabled by solution processing. Advanced Science, 13(16), e18844 (2025).
10. Chengqian Cui, Xize Gao, Jingwei Li, Nianzhen Du, Qin Li, Huimin Li, Changxiang Yan*, Mingjun Zhang*. Aggregation-enhanced piezoelectric nanotransducers facilitate transgene-free wireless neuromodulation under low-intensity focused ultrasound. ACS Nano, 20(1), 835-848 (2025).
11. S. Lenaghan, C. A. Davis, W. R. Henson, Z. Zhang, and Mingjun Zhang*. High-Speed Microscopic Imaging of Flagella Motility and Swimming in Giardia lamblia Trophozoites. Proceedings of the National Academy of Sciences (PNAS), 108 (34), 13891-13892 (2011).
12. Yongzhong Wang, Leming Sun, Sijia Yi, Yujian Huang, Scott C. Lenaghan and Mingjun Zhang*. Naturally Occurring Nanoparticles from Arthrobotrys oligospora as a Potential Immunostimulatory and Antitumor Agent. Advanced Functional Materials, 23, 2175 (2013).
13. Tiancheng Sheng, Jingwei Li, Lingyi Zheng, Nianzhen Du, Mingxiao Xie, XiaolongWang, Xize Gao, Mengsha Huang, Shenghan Wen, Wenqian Liu, Yong Guo, Yi Yao, Xiaoqiu Shao, Lianqing Liu, Jing Xu, Yilong Wang*, Mingjun Zhang*. An expandable brain-machine interface enabled by origami materials and structures for tracking epileptic traveling waves. Advanced Healthcare Materials, 14(11), 2404947 (2025).
14. Jingwei Li, Lingyi Zheng, Tiancheng Sheng, Mengsha Huang, Ziyi Wang, Lixi Ma, Yilong Wang, Xiaoqiu Shao, Changxiang Yan*, Mingjun Zhang*. Source tracing with spatial phase gradients in epileptiform activity localizes seizure onset zone. Journal of Neural Engineering, 22(6), 066006 (2025).
15. Xinghua Jia, Zongyao Chen, Andrew Riedel, Ting Si, William R. Hamel, Mingjun Zhang*. Energy-efficient Surface Propulsion Inspired by Whirligig Beetles. IEEE Transactions on Robotics, 31, 1432-1443 (2015).
16. Yang Jia, Gongxin Li, Wenxue Wang*, Jialin Shi, Meng Li, Ning Xi, Mingjun Zhang*, Lianqing Liu*. A bio-syncretic phototransistor based on optogenetically engineered living cells. Biosensors and Bioelectronics, 178, 113050 (2021).
开设课程：
微创脑机接口：理论及实践（全英文授课，Minimally Invasive Brain-machine Interfaces: Principles and Practices）
非线性神经动力学与生物智能（全英文授课, Nonlinear Neural Dynamics and Biological Intelligence）
微创脑机接口導論（全英文授课，Introduction to Minimally Invasive Brain-machine Interfaces）
技术专利：
1. 2025 Mingjun Zhang, Xize Gao, Jiacong Li, Jing Li, Jing Xu, Mingxiao Xie, Hongru Liu, Longxi Ren. Microneedle drug delivery apparatus and preparation method thereof, US patent, US-2026-0077170-A1.
2. 2025 Mingjun Zhang, Xize Gao, Jiacong Li, Jing Li, Jing Xu, Mingxiao Xie, Hongru Liu, Longxi Ren. MIKRONADEL-ARZNEIMITTELABGABEVORRICHTUNG UND HERSTELLUNGSVERFAHREN DAVON, Germany patent, DP11/2023/006/325.7.
3. 2025 张明君，高喜泽，李家聪，李靖，徐静，谢铭效，刘鸿儒，任龙喜。微针给药装置及其制备方法，中国专利，CN2023800597166.
4. 2025 王伊龙，张明君，高喜泽，刘向荣。一种NA1-白蛋白纳米颗粒及其制备方法和应用，中国专利，CN2025118620045.
5. 2024 Mingjun Zhang, Tiancheng Sheng and Lingyi Zheng, Stimulation Electrode Design and Fabrication, PCT/CN2024/132999.
6. 2022 Mingjun Zhang, Tiancheng Sheng and Mingxiao Xie, Foldable Expandable ECoG Electrode Design and Fabrication for Brain Machine Interface, PCT/CN2022/137957.
7. 2022 Zhang Mingjun, Gao Xize, Li Jiacong, Li Jing, Xu Jing, Xie Mingxiao, Liu Hongru, Ren Longxi. Microneedle drug administration apparatus and preparation method thereof, WO2024/243887 A1.
清华大学医学科学楼（清华大学西北门南行50米路西侧）
62787861 
sygcxybgs@mail.tsinghua.edu.cn
©2017 清华大学生物医学工程学院 版权所有
微信公众号
