Developing chip technologies and products for basic and clinical research, with multiple achievements successfully translated into industrial applications.

Conducted systematic and in-depth innovative research on chip design principles, manufacturing processes, lab-on-a-chip system integration, and supporting instruments. Developed a series of new technologies and products tailored to the needs of basic and clinical medicine.

Researcher Xing Wanli and her team are mainly engaged in the R&D of DNA chips, protein chips, cell chips, and lab-on-a-chip devices. Their research also covers applications in health management, disease diagnosis, food safety testing, and drug development, as well as big data and artificial intelligence-driven big health management based on the internet.

In the field of microarray chips:

Developed the world's first genetic testing chip for hereditary hearing loss, covering gene loci associated with congenital hearing loss, drug-induced hearing loss, and late-onset hearing loss. It features high accuracy, sensitivity, efficiency, and stability, solving the problem of trace sample genetic testing. A complete set of supporting instruments and overall solutions suitable for large-scale screening were also developed.

Developed chips for tuberculosis (TB) identification and drug resistance testing, shortening the conventional 4-8 week detection time to 6 hours. The product performance meets international advanced standards. The TB identification chip was named one of China's Top 10 Advanced Reagents in Laboratory Medicine in 2010, and the TB drug resistance chip was awarded the title of National Key New Product. Both products have been recognized as Beijing Independent Innovation Products.

In the field of cell biochips:Pioneered the world's first electrophysiological measurement biochip platform capable of non-destructive positioning control and multi-point detection of neural cell networks. It serves as an efficient platform for drug screening and neuroscience research and has been adopted by domestic research institutions.

In the field of immune biochips:As the project leader, developed the world's first veterinary drug residue detection chip system for food safety inspection. It has been applied by multiple entry-exit inspection and quarantine bureaus and other institutions.

In the field of microfluidic chips:Led the team to develop a disc-type pathogen detection system and a fully integrated chip system, which have been used in more than 600 hospitals and centers for disease control and prevention (CDCs).

1. "A pumpless liver-on-a-chip for drug hepatotoxicity analysis" Jiao, D., Xie, L. and Xing, W. Analyst, 2024, 149(18):4675-4686. 共同通讯作者（SCI IF: 3.6）

2. "A rapid method for isolation of bacterial extracellular vesicles from culture media using epsilon-poly-L-lysine that enables immunological function research" Wei, S., Jiao, D. and Xing, W. Frontiers in Immunology, 2022, 13:930510. 通讯作者（SCI IF: 5.7）

3. "Targeted Therapy of Lung Adenocarcinoma by the Nanoplatform Based on Milk exosomes Loaded with Paclitaxel" Chen, J., Cao, F., Cao, Y., Wei, S., Zhu, X. and Xing, W. Journal of Biomedical Nanotechnology, 2022, 18(4):1075-1083. 通讯作者（SCI IF: 2.9）

4. "A Highly Automated Mobile Laboratory for On-site Molecular Diagnostics in the COVID-19 Pandemic" Xing, W., Wang, J., Zhao, C., Wang, H., Bai, L., Pan, L., Li, H., Wang, H., Zhang, Z., Lu, Y., Chen, X., Shan, S., Wang, D., Pan, Y., Weng, D., Zhou, X., Huang, R., He, J., Jin, R., Li, W., Shang, H., Zhong, N., and Cheng, J. Clinical Chemistry, 2021, 67(4):672-683. 第一作者（SCI IF: 7.1）

5. "Exploratory development of PCR-fluorescent probes in rapid detection of mutations associated with extensively drug-resistant tuberculosis" Liang, J., An, H., Zhou, J., Liu, Y., Xiang, G., Liu, Y., Xing, W. and Gong, W. European Journal of Clinical Microbiology & Infectious Diseases, 2021, 40(9):1851-1861. 共同通讯作者（SCI IF: 3.7）

6. "A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2" Xing, W., Liu, Y., Wang, H., Li, S., Lin, Y., Chen, L., Zhao, Y., Chao, S,. Huang, X., Ge, S., Deng, T., Zhao, T., Li, B., Wang, H., Wang, L., Song, Y,. Jin, R., He, J., Zhao, X., Liu, P., Li, W., and Cheng, J. Engineering, 2020, 6:1130-1140. 第一作者（SCI IF: 10.1）

7. "Caffeine-free hawk tea lowers cholesterol by reducing free cholesterol uptake and the production of very-low-density lipoprotein" Feng, J., Yang, J., Chang, Y., Qiao, L., Dang, H., Luo, K., Guo, H., An, Y., Ma, C., Shao, H., Tian, J., Yuan, Y., Xie, L., Xing, W., and Cheng, J. Communications Biology, 2019, 2:173. 共同通讯作者（SCI IF: 5.2）

8. "Rapid and efficient isolation and detection of extracellular vesicles from plasma for lung cancer diagnosis" Chen, J., Xu, Y., Wang, X., Liu, D., Yang, F., Zhu, X., Lu, Y., and Xing, W. Lab on a Chip, 2019, 19(3): 432-443. 通讯作者（SCI IF: 6.1）

9. "Isolation and Visible Detection of Tumor-Derived Exosomes from Plasma" Chen, J., Xu, Y., Lu, Y., and Xing, W. Analytical Chemistry, 2018, 90(24):14207–14215. 通讯作者（SCI IF: 6.8）

10. "Sensitive and rapid detection of pathogenic bacteria from urine samples using multiplex recombinase polymerase amplification" Chen, J., Xu, Y., Yan, H., Zhu, Y., Wang, L., Zhang, Y., Lu, Y, and Xing, W. Lab on a Chip, 2018, 18(16):2441-2452. 通讯作者（SCI IF: 6.1）

Academic Honors and Awards

2020: 13th Tan Jiazhen Life Science Award (Industrialization Award)

2019: Huang Jiasi Biomedical Engineering Award (Second Class)

2019: Huaxia Medical Science and Technology Award (Second Class)

2018: National Technology Invention Award (Second Class)

2018: Chinese Medical Science and Technology Award (Second Class)

2018: Beijing Municipal Science and Technology Award (Second Class)

2018: National Technology Invention Award (Second Class, Rank 3)

2017: Huang Jiasi Biomedical Engineering Award (First Class)

2017: Beijing Municipal Science and Technology Award

2017: Beijing Municipal Invention Patent Award

2017: 19th China Patent Award

2016: Beijing Daxing District Science and Technology Progress Award (First Class)

2016: China Patent Award (Excellence Award) & Invention Patent Award (Third Class)

2016: 12th Batch of "Beijing Municipal Talents with Outstanding Contributions in Science, Technology and Management"

2015: Ministry of Education Innovative Teaching Achievement Award

2015: First National Maternal and Child Health Science and Technology Award (First Class)

2015: China Patent Award (Excellence Award)

2014: Beijing Municipal Science and Technology Award (Second Class), Chinese Medical Award (Second Class) & Huaxia Medical Award (Second Class)

2013: Chongqing Municipal Science and Technology Progress Award (First Class)

2012: "Advanced Worker of National Engineering Research Center" awarded by the National Development and Reform Commission

2011: Beijing Municipal "March 8th" Red Banner Medal

2007: Selected into the Ministry of Education's New Century Excellent Talents Support Program

2007: National Technology Invention Award (Second Class, Rank 2)

Courses Offered

Biochip Technology and Its Applications

Other Social Positions

October 2006 – Present: Standing Committee Member, Biochip Branch, China Pharmaceutical Biotechnology Association

September 2008 – Present: Secretary-General, National Technical Committee for Standardization of Biochips

May 2012 – Present: PI, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Recognized as a national-level "2011 Collaborative Innovation Center" by the Ministry of Education and the Ministry of Finance in October 2014)

December 2013 – Present: Member, Clinical Laboratory Standards Professional Committee, 7th National Health Standards Committee

December 2014 – Present: Deputy Director, Biomedical Industrialization Working Committee, China High-tech Industrialization Research Association

Representative Technical Patents

A Kit for Detecting Hereditary Hearing Loss by Co-labeling Magnetic Beads and Luminescent Substances (ZL201010527681.9)Inventors: Gao Huafang, Xiang Guangxin, Jiang Di, Xing Wanli, Cheng JingThis technology has been industrialized into a hereditary hearing loss genetic testing system, benefiting over 7.1 million newborns in hereditary hearing loss screening and saving nearly 30 billion yuan in national medical and health resources.

A Liquid Storage and Controlled Release Device and a Biological Detection Chip (ZL202010308399.5)Inventors: Zhou Xinying, Wang Lei, Bai Liang, Guo Tengfei, Li Shuo, Li Baolian, Zhuang Bin, Chen Xiang, Guo Hongju, Zhao Xiaolei, Xing Wanli, Cheng JingThis technology has been industrialized into a fully integrated disc-type chip system for COVID-19 nucleic acid detection, achieving "sample in-result out" in 45 minutes (positive results reported in 35 minutes) with a detection sensitivity of 150 copies/mL. It obtained emergency approval from the National Medical Products Administration on February 9, 2021.

Multi-index Detection Microfluidic Chip and Methods of Use (US10300483B2)Inventors: Wang Lei, Zhang Guohao, Zhou Xinying, Xin Juan, Zhang Yao, Lin Mingxian, Huang Guoliang, Wang Can, Xing Wanli, Cheng JingThis technology has been industrialized into an isothermal amplification microfluidic chip nucleic acid analysis system, which has been put into use in more than 600 hospitals nationwide.