Driving Independent Innovation of Domestic PET/CT Technology Through Medicine-Engineering Integration, Industry-University-Research-Medical Cooperation, and Clinical Demand Orientation
Dr. Zhang Hui’s research focuses on diagnostic and therapeutic imaging technologies represented by PET and CT imaging, including medical imaging physical mechanisms, imaging chains and core components, and imaging algorithms. Meanwhile, the research team is committed to promoting the integration of molecular imaging with robotic surgery and deep learning technologies, advancing the clinical application of integrated diagnosis-therapy precision molecular imaging.
PET/CT is one of the most advanced clinical imaging devices currently available, playing an indispensable role in the clinical diagnosis and treatment pathways of major diseases such as tumors, central nervous system disorders, and cardiovascular diseases. In collaboration with the Department of Nuclear Medicine, Peking Union Medical College Hospital, Dr. Zhang has been dedicated to the R&D and industrialization of high-end domestic PET/CT since 2011. By leveraging medicine-engineering integration and industry-university-research-medical cooperation, the team drives independent innovation of domestic PET/CT based on clinical needs.
The developed time-of-flight PET/CT products have reached or exceeded the level of international mainstream products in terms of performance indicators and clinical image quality. Pioneering technologies such as free-breathing imaging and passive quality control have also become leading technologies in the industry. To date, the products have obtained two National Medical Products Administration (NMPA) medical device registration certificates and one CE Certificate, been included in the 5th Batch of "Excellent Domestic Medical Equipment" catalog, and received support from the National Key R&D Program of China (13th Five-Year Plan) for Digital Diagnosis and Treatment Special Project’s domestic high-end medical equipment application demonstration program.
Additionally, the next-generation PET/CT products under development have once again achieved international leading performance indicators. Supported by the National Key R&D Program of China (13th Five-Year Plan) for Digital Diagnosis and Treatment Special Project’s PET core component R&D program, the team has realized domestic production of SiPM core components and ASIC chips for readout circuits, truly achieving independent control from the complete machine to core components.
Up to now, nearly 20 units of the developed PET/CT products have been installed in medical institutions at all levels, including Peking Union Medical College Hospital and Beijing Friendship Hospital, completing more than 50,000 clinical patient scans. The products have gained widespread recognition from industry experts and medical institutions.
1．Preoperative prediction of pathological grade in pancreatic ductal adenocarcinoma based on 18F-FDG PET/CT radiomics. Xing H, Hao Z, Zhu W, Sun D, Ding J,Zhang H, Liu Y, Huo L. EJNMMI Research, 2021.11(1):19.
2．Comparison of different kinetic models for dynamic F-18-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function,Geist, Barbara Katharina; Wang, Jingnan; Wang, Xuezhu; Lin, Jianzhen; Yang, Xu;Zhang, Hui; Li, Fang; Zhao, Haitao; Hacker, Marcus; Huo, Li; Li, Xiang，PhysicsinMedicineandBiology,2020.65(4) :045001
3．Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li,Hui Zhang*, Performance Evaluation of a New High-Sensitivity Time-of-Flight Clinical PET/CT System, EJNMMI Physics, 2018.5:29
4．Ximin Shi, Nan Li, Haiyan Ding, Yonghong Dang, Guilan Hu, Shuai Liu, Jie Cui, Yue Zhang, Fang Li,Hui Zhang, Li Huo*, Comparison among Reconstruction Algorithms for Quantitative Analysis of 11C-Acetate Cardiac PET Imaging, Contrast Media & Molecular Imaging, vol. 2018, Article ID 9193403, 10 pages, 2018. doi:10.1155/2018/9193403
5．Wenjia Zhu,Shaobo Yao,Haiqun Xing,Hui Zhang,Yuan-chuan Tai,Yingqiang Zhang,Yimin Liu,Yanru Ma,Chenxi Wu,Hongkai Wang,Zibo Li,Zhanhong Wu,Zhaohui Zhu,Fang Li,Li Huo*,Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [18F]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers.Molecular Imaging and Biology. 2016,18(5), 782-787
6．M Wang, N Guo, G Hu, G El fakhri,H Zhang*, Q Li*. A novel approach to assess the treatment response using Gaussian random field in PET. Medical Physics, 2016, 43(2): 833-842.（共同通讯作者）
7．Mengdie Wang, Guangshu Hu,Hui Zhang*. Performance comparison of dual-head PEM scanner by Monte Carlo simulation.Nuclear Inst. and Methods in Physics Research, A737C (2014):5-10.
8．Yilong Liu, Mengdie Wang, Jing Bai,Hui Zhang*. System response matrix calculation using symmetries for dual-head PET scanners.International journal of imaging systems and technology.23(2013):205–214.
9．Zhe Guo, Zhiwei Tang, Xinzeng Wang, Mingliang Deng, Guangshu Hu,Hui Zhang*. Performance Evaluation of a Modular Detector Unit forX-ray Computed Tomography.Sensors, 13(2013):5167-5180.
10．Zhiwei Tang, Guangshu Hu,Hui Zhang*.An efficient metal artifact reduction method based on improved total variation regularization.Journal of Medical and Biological Engineering, (2013) doi:10.5405/jmbe.1358.
11．Xin Liu, Xiaolian Guo, Fei Liu, Yi Zhang,Hui Zhang, Guangshu Hu, Jing Bai*. Imaging of Indocyanine Green Perfusion in Mouse Liverwith Fluorescence Diffuse Optical Tomography.IEEE Transactions on Biomedical Engineering. 58(2011): 2139 - 2143
12．Hui Zhang*, Qinan Bao, Nam T. Vu, Robert W. Silverman, Richard Taschereau, Brittany N. Berry-Pusey, Ali Douraghy, Fernando R. Rannou, David B. Stout and Arion F. Chatziioannou. Performance Evaluation of PETbox: a Low Cost Bench Top Preclinical PET Scanner.Molecular Imaging and Biology. 13(2011):949-961
13．Xin Liu,Xiaolian Guo,Fei Liu,Yi Zhang,Hui Zhang,Guangshu Hu,Jing Bai.Imaging of Indocyanine Green Perfusion in Mouse Liver With Fluorescence Diffuse Optical Tomography.IEEE Transactions onBiomedical Engineering.58(2011): 2139 – 2143.
14．Hui Zhang, Nam T. Vu, Qinan Bao, Robert W. Silverman, Brittany N. Berry-Pusey, Ali Douraghy, Darin A. Williams, Fernando R. Rannou, David B. StoutandArion F. Chatziioannou.Performance Characteristics of BGO Detectors for a Low Cost Preclinical PET Scanner.IEEE Transactions on Nuclear Science.57(2010):1038-1044
