We have been innovating in the field of 'icrotissue Engineering’, with accomplishment in the theoreticaelucidation and technological translation. icrotissue Engineering integrates biomaterials, microfabrication,biophysical and gene editing technologies to engineer and fine-tune the microscale 3D cell or tissuemicroenvironments, whichprovides innovative and effective tools and solutions for regenerative medicine, drugdiscovery and pathology study. We focus on1establishment of stem cell microenvironment, immune celmicroenvironment as well as fibrosis pathological microenvironments, 2)the mechanism investigation of cecell, cell-matrix interactions and3)their translational applications in regenerative medicine.

Specifically, through theconstruction of 3D stem cell micro-tissue, large-scale/high-quality in vitro stemcellmanufacture and minimally invasive, targeted, efficient in vivo delivery andregeneration treatment have beenaccomplished; meanwhile, the 3D pathological micro-tissuearray technology realized high-throughput andaccurate anti-fibrosis druascreening and evaluation, The new patholodical mechanism of celmechanicalcommunication basedon 'paratensile signaling' in the development of tissuefibrosis was discovered2patents of micro-tissue engineering have been commercially translated with relatedproducts approved as thefirst cell pharmaceutical excipients by both China CDE and US FDA

Lab web:http://dulab-tsinghua.net/

1.Exendin-4 Gene-modification and Microscaffold Encapsulation Promote Self-persistence and Anti-diabetic Activity of MSCs,Science Advances, 2021, DOI: 10.1126/sciadv.abi4379

2.Matrix -transmitted paratensile signaling enables myofibroblast-1 fibroblast crosstalk in fibrosis expansion,PNAS, 2020, 03(27): 4-27

3.Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D,Nature Communications, 2019, 10: 0-3491

4.Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis,Nature Materials, 2017, 16(12): 1252-1261

5.Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia,PNAS, 2014, 111(37): 13511-13516